European shellfish farming enjoys a prominent position on a global scale. The European production of shellfish relies mostly on mussels, oysters and clams. Approximately 8,500 companies employ more than 42,000 people. However, over the recent years, a growing number of mortality cases, associated to pathogen organisms, have been observed. The European VIVALDI project aimed to improve the sustainability and competitiveness of the European shellfish industry by developing tools and approaches to prevent and mitigate the impact of bivalve diseases.